**Contents**show

## How do you solve the Hardy-Weinberg equation?

The Hardy-Weinberg equation used to determine genotype frequencies is: p^{2} + 2pq + q^{2} = 1. Where ‘p^{2}‘ represents the frequency of the homozygous dominant genotype (AA), ‘2pq’ the frequency of the heterozygous genotype (Aa) and ‘q^{2}‘ the frequency of the homozygous recessive genotype (aa).

## How do you calculate P and Q?

We can calculate the values of p and q, in a representative sample of individuals from a population, by simply counting the alleles and dividing by the total number of alleles examined. For a given allele, homozygotes will count for twice as much as heterozygotes.

## How do you calculate heterozygote frequency?

The frequency of heterozygous individuals. Answer: The frequency of heterozygous individuals is equal to 2pq. In this case, 2pq equals 0.32, which means that the frequency of individuals heterozygous for this gene is equal to 32% (i.e. 2 (0.8)(0.2) = 0.32).

## How do you find the Hardy-Weinberg allele frequency?

To calculate the allelic frequencies we simply divide the number of S or F alleles by the total number of alleles: 94/128 = 0.734 = p = frequency of the S allele, and 34/128 = 0.266 = q = frequency of the F allele.

## What is 2pq?

In the equation, p^{2} represents the frequency of the homozygous genotype AA, q^{2} represents the frequency of the homozygous genotype aa, and 2pq represents the frequency of the heterozygous genotype Aa.

## What is p2 2pq q2?

p^{2} + 2pq + q^{2} = 1 mathematically represents Hardy-Weinberg’s principle used to calculate the genetic variation of a population at equilibrium. It states that the allele frequencies in a population are stable and remain constant from one generation to another.

## How do you calculate carrier frequency?

The carrier frequency can then be calculated as 2X99/100×1/100 which approximates to 1 in 50. Thus a rough approximation of the carrier frequency can be obtained by doubling the square root of the disease incidence. For an X-linked disorder the frequency of affected males equals the frequency of the mutant allele, q.

## How do you calculate heterozygosity?

The calculation of heterozygosity can be done directly by adding the frequency of the (three) heterozygote classes directly, or by adding the frequencies of the (three) homozygote classes and subtracting the total from unity.

## How do you solve for allele frequencies?

To find the allele frequencies, we again look at each individual’s genotype, count the number of copies of each allele, and divide by the total number of gene copies.

## How do you calculate allele frequency?

An allele frequency is calculated by dividing the number of times the allele of interest is observed in a population by the total number of copies of all the alleles at that particular genetic locus in the population. Allele frequencies can be represented as a decimal, a percentage, or a fraction.

## How do you calculate phenotype frequency?

To compare different phenotype frequencies, the relative phenotype frequency for each phenotype can be calculated by counting the number of times a particular phenotype appears in a population and dividing it by the total number of individuals in the population.