What do mitotic figures indicate?
A mitotic figure is a cell that is in the process of dividing to create two new cells. This process is called mitosis. Pathologists can see mitotic figures when they look at tissue under the microscope.
Does mitotic figures mean cancer?
A measure of how fast cancer cells are dividing and growing. To find the mitotic rate, the number of cells dividing in a certain amount of cancer tissue is counted. Mitotic rate is used to help find the stage of melanoma (a type of skin cancer) and other types of cancer.
What does high mitotic rate mean?
The higher the mitotic count, the more likely the tumor is to have metastasized (spread). The logic is that the more cells are dividing, the more likely they will invade the blood or lymphatic vessels and thus spread around the body.
What is the importance of mitotic index in understanding cell cycle?
In cancer cells, the mitotic index may be elevated compared to normal growth of tissues or cellular repair of the site of an injury. The mitotic index is therefore an important prognostic factor predicting both overall survival and response to chemotherapy in most types of cancer.
What is mitosis important?
Mitosis is important to multicellular organisms because it provides new cells for growth and for replacement of worn-out cells, such as skin cells. Many single-celled organisms rely on mitosis as their primary means of asexual reproduction.
What does mitotic mean in medical terms?
Mitosis: The ordinary division of a body cell (a somatic cell) to form two daughter cells, each with the same chromosome complement as the parent cell.
What is differentiated squamous cell carcinoma?
Squamous cell carcinoma has been defined as, ‘a malignant epithelial neoplasm exhibiting squamous differentiation as characterized by the formation of keratin and/or the presence of intercellular bridges.
What is the meaning of mitotic?
1. The process in cell division by which the nucleus divides, typically consisting of four stages, prophase, metaphase, anaphase, and telophase, and normally resulting in two new nuclei, each of which contains a complete copy of the parental chromosomes. Also called karyokinesis. 2.
What are rare mitotic figures?
Answer. Mitotic figures are rare in the epithelium of benign and neoplastic prostate cells, but mitosis progressively increases during the transition from benign to PIN to malignancy. Mitotic figures in BPH are found in the basal cell, with a mean value of 0.002%.
What is mitotic rate and how is it used to determine prognosis?
However, for patients with a mitotic rate between 5.00 and 20.00 mitoses/mm2, the 5-year survival rates in patients with pathologic stage I and II disease were 6% to 13% higher than in patients with clinical stage I and II disease.
What is a cancerous mitotic index?
(my-TAH-tik IN-dex) In a population of cells, the ratio of the number of cells undergoing mitosis (cell division) to the number of cells not undergoing mitosis.
What would you expect to happen to the mitotic index of a population of cells that loses the ability to divide as they mature?
What would happen to the mitotic index to a population of cells that mature? The mitotic index would drop as the loss of their ability to divide will result in a smaller ratio of cells in mitosis to overall cells.
What affects the mitotic index?
The number of cells in mitosis were counted for cells from different regions of the primary root tissue. Interpretation: In general, the mitotic index decreases with increasing distance from the root cap junction.
What is the connection between the mitotic index and how often a cell divides?
The mitotic index measures the rate of cell division. It is defined as the percentage of cells undergoing mitosis (in prophase, metaphase, anaphase, or telophase) compared to the total number of cells in a population.