What makes up the mitotic spindle?
The mitotic spindle is a highly dynamic molecular machine composed of tubulin, motors, and other molecules. It assembles around the chromosomes and distributes the duplicated genome to the daughter cells during mitosis.
What are the two parts of the mitotic spindle in animal cells?
The spindle is a self-organized bipolar array of microtubules. The minus ends of the microtubules are focused into the spindle poles, which is where the centrosomes reside to nucleate and organize spindle microtubules.
Which is the major component of mitotic spindle?
Spindle fibers are made up of microtubules and they appear as spindle-shaped structures (thus, the name). They develop outside the nucleus during mitosis. The major components of the mitotic spindle include the spindle fibers (microtubules), microtubule-associated proteins, and the microtubule organizing center.
What are the parts of spindle apparatus?
The cellular spindle apparatus includes the spindle microtubules, associated proteins, which include kinesin and dynein molecular motors, condensed chromosomes, and any centrosomes or asters that may be present at the spindle poles depending on the cell type.
What are the 3 types of spindle microtubules?
The overall shape of the spindle is framed by three types of spindle microtubules: kinetochore microtubules (green), astral microtubules (blue), and interpolar microtubules (red).
What is the mitotic spindle quizlet?
An assemblage of microtubules and associated proteins that is involved in the movements of chromosomes during mitosis.
What are the three types of spindle microtubules and what is the function of each?
The mitotic spindle is composed of three distinct types of microtubule fibers (kinetochore microtubules, polar microtubules, and aster microtubules; all emanating from the centrosomes), and they serve to pull and push the sister chromatids apart toward opposite spindle poles.
What are the components of mitotic apparatus?
In eukaryotic cells, the mitotic apparatus is composed of two centrosomes and spindle microtubules (Figure 43.9). The centrosome is 1–2 μm in diameter. Each centrosome is composed of two centrioles of approximately 20 nm in diameter surrounded by a pericentriolar matrix.
What are the four stages of mitosis?
These phases are prophase, prometaphase, metaphase, anaphase, and telophase.
How many types of spindles are there?
There are 2 types of spindle fibres which are identified – the interpolar fibre, stretching continuously from one to another of the spindle; kinetochore fibre.
What is the role of the mitotic spindle?
The mitotic spindle is the macromolecular machine that segregates chromosomes to two daughter cells during mitosis. The major structural elements of the spindle are microtubule polymers, whose intrinsic polarity and dynamic properties are critical for bipolar spindle organization and function.