What is the role of chromatin in transcriptional regulation?

In eukaryotes, the tight or loose packaging of the genes in chromatin (DNA plus specific proteins) can control whether the genes can be expressed to form their encoded product. DNA itself can be methylation and that also regulates gene expression, generally to turn off the gene. …

What does chromatin do in transcription?

Interestingly, chromatin not only serves as a way to condense DNA within the cellular nucleus, but also as a way to control how that DNA is used. In particular, within eukaryotes, specific genes are not expressed unless they can be accessed by RNA polymerase and proteins known as transcription factors.

Is chromatin involved in transcription?

Chromatin remodelling complexes function by increasing nucleosome mobility and are clearly implicated in transcription. … These results indicate that chromatin remodelling driven by the Ino80 ATPase may be connected to transcription as well as DNA damage repair.

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What is the relationship of chromatin structure to transcription?

Chromatin is a dynamic structure that not only helps to package the entire eukaryotic genome into the confines of the nucleus but also regulates the accessibility of DNA for transcription, recombination, DNA repair and replication.

What is involved in transcriptional regulation?

In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity. … This control allows the cell or organism to respond to a variety of intra- and extracellular signals and thus mount a response.

How do chromatin modifications regulate transcription?

Functional Consequences of Histone Modifications

To establish a global chromatin environment, modifications help partition the genome into distinct domains such as euchromatin, where DNA is kept “accessible” for transcription, and heterochromatin, where chromatin is “inaccessible” for transcription.

Why is chromatin remodeling important?

Chromatin remodeling is an important mechanism of regulating eukaryotic gene expression, which makes tightly condensed DNA accessible to various regulatory factors, such as transcription factors and components of DNA replication.

How does chromatin remodeling work?

Chromatin remodeling is the rearrangement of chromatin from a condensed state to a transcriptionally accessible state, allowing transcription factors or other DNA binding proteins to access DNA and control gene expression.

What is the role of the repressor protein in the transcription of the trp operon quizlet?

What is the role of the repressor protein in the transcription of the trp operon? The repressor protein binds to the operator site and prevents the transcription of the trp operon.

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How does chromatin regulate gene expression?

In eukaryotes, the tight or loose packaging of the genes in chromatin (DNA plus specific proteins) can control whether the genes can be expressed to form their encoded product. DNA itself can be methylation and that also regulates gene expression, generally to turn off the gene. …

How might chromatin structure be involved in such regulation?

How might chromatin structure be involved in such regulation? DNA loops are thought to bring distant enhancer or silencer elements into proximity with promoter regions of the genes under their regulation. … In general, periodic methylation occurs at CpG-rich regions and promoter sequences.

What are histones and what is the principal role in chromatin structure?

What are histones and what is their principal role in chromatin structure? Ans: Histones are small basic proteins that bind to DNA. There are five main types, four of which interact with each other to form the core of the nucleosome around which the DNA is wrapped.

What is the association of chromatin nuclear location with transcriptional activity?

Associations of large regions of chromatin, termed lamin associated domains (LADs) with the nuclear lamina is generally associated with transcriptional repression [52], however relocation to the periphery is not always sufficient for gene silencing [53], nor is it necessary as many inactive loci are located within the …

How do transcription factors play a role in transcriptional regulation?

Transcription factors are proteins that regulate the transcription of genes—that is, their copying into RNA, on the way to making a protein. … Transcription factors help ensure that the right genes are expressed in the right cells of the body, at the right time.

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Why is chromatin important?

Chromatin is the material that makes up a chromosome that consists of DNA and protein. The major proteins in chromatin are proteins called histones. They act as packaging elements for the DNA. The reason that chromatin is important is that it’s a pretty good packing trick to get all the DNA inside a cell.

What is the role of repressor proteins in the regulation of transcription?

A repressor is a protein that has a negative effect on gene expression. So these usually are proteins that bind to DNA, and they either prevent the RNA transcription machinery from getting in there and transcribing that DNA, or they just slow it down.