Colchicine is an alkaloid derived from the autumn crocus (Colchicum autumnale). It inhibits mitosis by inhibiting microtubule polymerization. While colchicine is not used to treat cancer in humans, it is commonly used to treat acute attacks of gout.
Does colchicine inhibit mitosis?
The alkaloid drug, colchicine, extracted from the corm of the autumn crocus (Colchicum autumnale), arrests mitosis in metaphase by interfering with the formation of spindle fibrils, thereby retarding the division of the centromeres and preventing division of the centrioles.
Which drugs are classified as mitotic inhibitors?
Examples of mitotic inhibitors frequently used in the treatment of cancer include paclitaxel, docetaxel, vinblastine, vincristine, and vinorelbine. Colchicine and griseofulvin are mitotic inhibitors used in the treatment of gout and toenail fungus, respectively.
Does colchicine stimulate mitosis?
Colchicine appears to have a stimulatory effect sometime during the mitotic cycle; it is this stimulation that results in the increase in the number of cells seen in division 1-2 days after treatment.
What effect does colchicine have on mitosis?
Colchicine exerts a toxic effect on living cells which commonly results in the arrest of the process of mitosis at an early stage, usually the metaphase, with the production of bizarre and abnormal nuclear configurations, and frequently leading to cell death.
Why do drugs such as colchicine inhibit mitosis?
Colchicine is a classical anti-mitotic drug which blocks mitotic cells in metaphase. It binds to soluble tubulin to form tubulin-colchicine complexes in a poorly reversible manner, which then binds to the ends of microtubules to prevent the elongation of the microtubule polymer.
Why colchicine is called as the mitotic poison?
(a)Colchicine is an alkaloid obtained from the corms of Autumn crocus. The alkaloid inhibits the formation of spindle by preventing assembly of microtubules. … As a result, the colchicine treated meristematic cells show doubling of chromosome.
What is colchicine mitosis?
Colchicines prevent spindle formation during mitotic metaphase. Thus, it prevents the separation of chromosomes during anaphase stage.
Which antineoplastic drugs are classified as antimetabolites?
Antimetabolites are group of anticancer agents that exert their cytotoxic effects by interfering with the DNA synthesis. Some of the important drugs from this class are 5-fluorouracil (5-FU), capecitabine, floxuridine, cytarabine, gemcitabine, decitabine, and vidaza.
What mitotic structure is targeted by vincristine and colchicine and what effect would that have on cell division?
Chemotherapy drugs such as vincristine (derived from Madagascar periwinkle plants) and colchicine (derived from autumn crocus plants) disrupt mitosis by binding to tubulin (the subunit of microtubules) and interfering with microtubule assembly and disassembly.
What is the action of colchicine?
Colchicine modulates multiple pro- and antiinflammatory pathways associated with gouty arthritis. Colchicine prevents microtubule assembly and thereby disrupts inflammasome activation, microtubule-based inflammatory cell chemotaxis, generation of leukotrienes and cytokines, and phagocytosis.
Is colchicine toxic to cells?
Because of its toxic effects, intravenous injection of colchicine has been banned, but it is still widely administered orally. We assayed the toxic effects of colchicine in cultured primary chorionic villus cells and amniotic fluid cells to interpret its influence on the placenta and foetus.
What are the side effects of colchicine?
Diarrhea, nausea, cramping, abdominal pain, and vomiting may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.