Question: What is the outcome of nondisjunction in meiosis I?

If nondisjunction occurs during anaphase I of meiosis I, this means that at least one pair of homologous chromosomes did not separate. The end result is two cells that have an extra copy of one chromosome and two cells that are missing that chromosome.

What happens if nondisjunction occurs during meiosis 1?

Nondisjunction can occur during either meiosis I or II, with differing results (Figure 1). If homologous chromosomes fail to separate during meiosis I, the result is two gametes that lack that particular chromosome and two gametes with two copies of the chromosome.

What is the end result when a nondisjunction occurs during meiosis I?

Nondisjunction in meiosis I occurs when the tetrads fail to separate during anaphase I. At the end of meiosis I, there will be 2 haploid daughter cells, one with n+1 and the other with n-1.

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What is the effect of nondisjunction in meiosis?

Nondisjunction in meiosis can result in pregnancy loss or birth of a child with an extra chromosome in all cells, whereas nondisjunction in mitosis will result in mosaicism with two or more cell lines. Aneuploidy may also result from anaphase lag.

What is the end result of nondisjunction?

Nondisjunction results in daughter cells with abnormal chromosome numbers (aneuploidy).

Which describes the cells at the end of meiosis 1 when nondisjunction occurs during meiosis 2?

One cell with extra homologous chromosomes and one cell missing a homologous chromosome. Which describes the cells at the end of meiosis I when nondisjunction occurs in meiosis II? The homologous pairs are in separate cells. The cells are haploid.

What happens if nondisjunction takes place during meiosis quizlet?

If nondisjunction occurs during meiosis I, homologous chromosomes fail to separate. This produces abnormal gametes that contain two members of the affected chromosome or none at all. If nondisjunction occurs during meiosis II, sister chromatids fail to separate.

How do nondisjunction errors in meiosis lead to aneuploidies such as trisomies and Monosomies?

Aneuploidy is caused by nondisjunction, which occurs when pairs of homologous chromosomes or sister chromatids fail to separate during meiosis. The loss of a single chromosome from a diploid genome is called monosomy (2n-1), while the gain of one chromosome is called trisomy (2n+1).

What happens in meiosis I?

In meiosis I, chromosomes in a diploid cell resegregate, producing four haploid daughter cells. It is this step in meiosis that generates genetic diversity. DNA replication precedes the start of meiosis I. During prophase I, homologous chromosomes pair and form synapses, a step unique to meiosis.

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What are the implications of nondisjunction?

Nondisjunction occurs when chromosomes fail to segregate during meiosis; when this happens, gametes with an abnormal number of chromosomes are produced. The clinical significance is high: nondisjunction is the leading cause of pregnancy loss and birth defects.

What does nondisjunction lead to?

Nondisjunction causes errors in chromosome number, such as trisomy 21 (Down syndrome) and monosomy X (Turner syndrome). It is also a common cause of early spontaneous abortions.

What is the result of nondisjunction which results in an extra chromosome in the cell nucleus?


Prior to or at conception, a pair of 21st chromosomes in either the sperm or the egg fails to separate. As the embryo develops, the extra chromosome is replicated in every cell of the body. This type of Down syndrome, which accounts for 95% of cases, is called trisomy 21.

What occurs during nondisjunction and the effect of the resulting cells?

The purpose of meiosis is to make gametes, also known as sperm and egg cells. … Describe what occurs during nondisjunction and the effect on resulting cells. – Nondisjunction would cause genetic disorders. This occurs when Mitosis is not completed correctly.

How does nondisjunction during meiosis I differ from nondisjunction in meiosis II?

Nondisjunction can occur during meiosis I and meiosis II, resulting in abnormal chromosomes number of gametes. The key difference between nondisjunction in meiosis 1 and 2 is that during meiosis 1, homologous chromosomes fail to separate while in meiosis II sister chromatids fail to separate.

How nondisjunction can result in an aneuploid zygote?

In humans, chromosome changes due to nondisjunction during mitosis in body cells will not be passed on to children (because these cells don’t make sperm and eggs). … When an aneuploid sperm or egg combines with a normal sperm or egg in fertilization, it makes a zygote that is also aneuploid.

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