What genotype is resistant to malaria?

Sickle cell trait (genotype HbAS) confers a high degree of resistance to severe and complicated malaria [1–4] yet the precise mechanism remains unknown.

What blood type is resistant to malaria?

Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting.

Who is resistant to malaria?

Types of innate resistance

  • Distribution of abnormal hemoglobins.
  • Sickle-cell.
  • Thalassemias.
  • HbC and HbE erythroids.
  • Glucose-6-phosphate dehydrogenase deficiency.
  • PK deficiency.
  • Elliptocytosis.
  • Southeast Asian ovalocytosis.

Is AA genotype prone to malaria?

Children with genotype AA (92.3%) were more susceptible to malaria parasite than AS (5.1%) and SS (2.6%). The association of haemoglobin genotype with malaria was highly significant (p<0.001).

Is there an AA blood type?

Thus it’s possible that the child’s blood type will be A (AO) or O (OO). Matters are a little simpler in the Rh system, with two possibilities: either the antigen RhD is present (Rh positive) or not (Rh negative). Positive is dominant over negative.

The Rh system.

Genes Blood type
A0 A
B0 B

Is malaria resistant to chloroquine?

Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

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What genotype has the highest fitness in areas with malaria?

Of the three genotypes, βAβS has the highest fitness by being partly protected from both anemia and malaria. The loss of βS alleles due to anemia is compensated (at equilibrium) by the loss of βA alleles from malaria, and thus both alleles are maintained in a state of balanced polymorphism.

What is the action of chloroquine?

The major action of chloroquine is to inhibit the formation of hemozoin (Hz) from the heme released by the digestion of hemoglobin (Hb). The free heme then lyses membranes and leads to parasite death. Chloroquine resistance is due to a decreased accumulation of chloroquine in the food vacuole.

What genotype is the best?

Health Tips

  • Types of Genotype. The genotypes in humans are AA, AS, AC, SS. They refer to the hemoglobin gene constituents on the red blood cells. …
  • Compatible genotypes for marriage are: AA marries an AA. That’s the best compatible. …
  • Solution. The only thing that can change the genotype is the bone marrow transplant (BMT).

What is the genotype of O+ blood group?

This is because the dominant A allele will overshadow the recessive O allele. However, if someone were to have the genotype AB, they would have blood type AB because both the A and B alleles are dominant.


Blood Type Genotype
Blood Type B Genotypes BB or BO
Blood Type AB Genotype AB
Blood Type O Genotype OO

What are the 3 types of genotypes?

There are three types of genotypes: homozygous dominant, homozygous recessive, and hetrozygous.

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What is my genotype?

In a nutshell: your genotype is your complete heritable genetic identity; the sum total of genes transmitted from parent to offspring. There are four hemoglobin genotypes (hemoglobin pairs/formations) in humans: AA, AS, SS and AC (uncommon). SS and AC are the abnormal genotypes or the sickle cells.

CAN A+ and O+ have a baby?

An A+ parent and an O+ parent can definitely have an O- child.

How do I know my genotype?

Sometimes a genetic test will give you your genotype. Sometimes you just need a bit of genetic luck in your family tree to figure it out. And sometimes you can tell the two genotypes apart just by looking at someone. An obvious way to figure out you genotype is to have a genetic test done.