Examples of mitotic inhibitors frequently used in the treatment of cancer include paclitaxel, docetaxel, vinblastine, vincristine, and vinorelbine.
What are mitotic drugs?
Mitotic inhibitors are drugs derived from natural plant sources. They inhibit cell division or mitosis, where a single cell divides into two genetically identical daughter cells. Mitotic inhibitors bind to tubulin and inhibit its polymerization into microtubules.
What do you mean by mitotic inhibitor?
Listen to pronunciation. (my-TAH-tik in-HIH-bih-ter) A type of drug that blocks cell growth by stopping mitosis (cell division). They are used to treat cancer.
Is cisplatin a mitotic inhibitor?
Chemotherapeutic agents include alkylating agents (cyclophosphamides), anthracycline antibiotics (doxorubicin), platinum compounds (cisplatin), mitotic inhibitors (vincristine), antimetabolites (5-fluorouracil), camptothecin derivatives (topotecan), biological response modifiers (interferon), and hormonal therapies ( …
Which chemotherapy medication is called a mitotic inhibitor because it is cell cycle specific for the M mitosis phase of the cell cycle?
Paclitaxel is a mitotic inhibitor capable of promoting tubulin polymerisation to microtubules and stabilising them. It blocks cell cycle progression in G2–M. It is an approved therapeutic agent in the management of NSCLC, ovarian and breast cancer, and Kaposi sarcoma.
Is vincristine a mitotic inhibitor?
A group of mitotic inhibitors (vinblastine, vincristine, and vinorelbine) exert their cytotoxic effects by binding to tubulin. This inhibits formation of microtubules, causing metaphase arrest.
What are antimetabolite drugs?
Antimetabolites are a form of chemotherapy drug. They’re one of the most commonly used therapies to treat cancer. And they’re one of the oldest, dating back to the 1940s, when doctors used a medication that’s now considered an antimetabolite to treat children with leukemia.
What is colchicine mitosis?
Colchicines prevent spindle formation during mitotic metaphase. Thus, it prevents the separation of chromosomes during anaphase stage.
What drugs are vinca alkaloids?
Vinca alkaloids include vinblastine, vincristine, vindesine, and vinorelbine originally derived from Catharanthus roseus (Apocynaceae). They are well-known clinical cytotoxic drugs inhibiting the ability of cancer cells to divide .
What is the meaning of mitotic?
1. The process in cell division by which the nucleus divides, typically consisting of four stages, prophase, metaphase, anaphase, and telophase, and normally resulting in two new nuclei, each of which contains a complete copy of the parental chromosomes. Also called karyokinesis. 2.
Why does Taxol inhibit mitosis?
Together these observations strongly indicate that the mechanism of inhibition of mitosis by taxol is due to inhibition of microtubule dynamics.
What effect does colchicine have on mitosis?
Colchicine exerts a toxic effect on living cells which commonly results in the arrest of the process of mitosis at an early stage, usually the metaphase, with the production of bizarre and abnormal nuclear configurations, and frequently leading to cell death.
What are microtubule inhibitors?
Microtubule inhibitors (MTI) such as taxanes, vinca alkaloids, and epothilones stabilize or destabilize microtubules, thereby suppressing microtubule dynamics required for proper mitotic function, effectively blocking cell cycle progression and resulting in apoptosis.
What is the name of oral chemotherapy drugs?
Some examples of oral chemotherapy medications include:
- Femara (letrozole)
- Odomzo (sonidegib)
- Jakafi (ruxolitinib)
- Zytiga (abiraterone)
- Hexalen (altretamine)
- Ibrance (palbociclib)
- Matulane (procarbazine)
- Sutent (sunitinib)
What is cytotoxic medication used for?
Cytotoxic drugs (sometimes known as antineoplastics) describe a group of medicines that contain chemicals which are toxic to cells, preventing their replication or growth, and so are used to treat cancer. They can also be used to treat a number of other disorders such as rheumatoid arthritis and multiple sclerosis.
Which drugs are used in chemotherapy?
- Abraxane (chemical name: albumin-bound or nab-paclitaxel)
- Adriamycin (chemical name: doxorubicin)
- carboplatin (brand name: Paraplatin)
- Cytoxan (chemical name: cyclophosphamide)
- daunorubicin (brand names: Cerubidine, DaunoXome)
- Doxil (chemical name: doxorubicin)
- Ellence (chemical name: epirubicin)